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Tirzepatide represents a novel class of medications known as dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists

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These gastrointestinal symptoms are typically most pronounced during dose escalation and often diminish over time as patients develop tolerance

"Human growth hormone-releasing factor (hGRF) analogs: structure-activity relationships and pharmacokinetics." Peptides 16.4 (1995): 705711

Molecular mechanisms of semaglutide and liraglutide GLP-1 receptor activation GLP-1 is an incretin hormone secreted by enteroendocrine L-cells and -cells in the pancreas and central nervous system