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Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration
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Medications: Certain long-term medications can interfere with glutathione production or increase its consumption
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The same research group further examined the gene expression of AGAT and GAMT in the liver, kidneys, and skeletal muscle with additional four fish species (maraena whitefish, pikeperch, European perch, and Atlantic herring) and demonstrated that the skeletal muscle possessed the highest abundances of mRNAs for both enzymes among all these tissues
