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On the other hand, direct modulation of metabolism and mediation of FGF21s cytoprotective effects in liver, described below, likely requires agonism of FGFR2c and possibly FGFR3c

2011 Sep;112(3):215-8

SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease

With this recent discovery, we are on track towards sustaining the quality of life for people suffering from neurodegenerative disorders such as Alzheimers disease.