Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism, 24 (8): 15531564
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Trulicity belongs to the GLP-1 receptor agonists class, miming natural incretin hormones in the body
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Furthermore, in signaling studies that used cell lines with recombinantly expressed human GIPR or GLP-1R, tirzepatide stimulated cyclic adenosine monophosphate (cAMP) accumulation by either receptor with potency similar to that of native GIP and approximately 13-fold weaker than that of native GLP-1 [1]