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With the successive promulgation of documents such as the General Rules for Land Space Control in the Core Monitoring Zone of the Grand Canal in Zhejiang Province and the Rules for Land Space Control in the Core Monitoring Zone of the Hangzhou Section of the Grand Canal, the issue of value conflicts between heritage preservation of the Grand Canal and local regional development has increasingly drawn attention

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Theoretical concerns include angiogenesis-related risk in patients with current or prior cancer, and effects on nitric oxide signaling that could matter for blood pressure