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The mechanism involves multiple pathways working simultaneously

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Released rapidly in response to nutrient ingestion, especially carbohydrates and fats, it enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner, effectively lowering postprandial blood glucose without risking hypoglycemia

That projection starts with first half 2025 semaglutide sales of about $16.4 billion (Ozempic about $9.4 billion, Wegovy roughly $5.4 billion, Rybelsus about $1.7 billion), annualizes that run rate to approximately $33 billion for full-year 2025, and incorporates Novos statement that recent U.S