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As you eat more food and gain more weight, you expend more energy, so an initial 100 calorie surplus for instance, eventually becomes maintenance calories over time
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These include medication cost, access, insurance coverage, long-term adherence, adverse-effect burden, management of weight regain after discontinuation, long-term effects on lean mass and bone density, and optimization of combination strategies
Health risks and interventions in prediabetes: a review
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