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The difference lies in the active peptide

Knee pain is a symptom with many possible causes, and successful treatment depends on an accurate diagnosis, appropriate patient selection, and a comprehensive plan

Neither is preferred for patients with a history of thyroid cancer, severe gastroparesis or a personal/family history of medullary thyroid carcinoma

The trial showed the drug was so effective, it seems, that an independent panel recommended there was no need to continue. ( source ) In addition to my personal opinion, there is widespread belief in the medical profession that the benefits outweigh the risks for a significant percentage of people in the United States