Morbid obesity in PWS leads to increased risk of cardiopulmonary compromise, type 2 diabetes mellitus (DM), chronic leg edema, premature cardiovascular disease, and death [1,2]
Our projected 24% reduction in cardiovascular events in persons with overweight or obesity but without cardiovascular disease from tirzepatide compares favorably to the well-publicized SELECT trial published last year involving another weight-loss medication Wegovy (semaglutide 2.4 milligram), which was studied in persons with cardiovascular disease and showed a 20% reduction in future cardiovascular events, said Wong, who also previously published a similar analysis of semaglutide estimating an 18% risk reduction in persons without cardiovascular disease
Peptides that sit in hot warehouses, ship without ice packs, or arrive in non-insulated packaging can degrade significantly before you ever open the vial
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Immunogenicity As with all therapeutic proteins and peptides, there is a potential for the development of an immune response in the form of anti-drug antibodies (ADAs)