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It is contraindicated in patients with uncontrolled hypertension, cardiovascular disease, or who are using MAOIs

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Assuming a functionally intact ileum, the vitamin B12/intrinsic factor complex is taken up into the enterocyte at this point in the small intestine

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Yet AC-SINS is limited in its utility for formulation development because the required pH of the test solution is higher than typical mAb formulation conditions