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Liraglutide, a GLP-1 receptor agonist, has also been tested in milk sEV-liraglutide oral liquid formulations, but it failed to lower blood glucose levels in mouse models, consistent with our own finding that liquid formulations are ineffective for oral delivery 30
SURMOUNT-4: the maintenance question Perhaps the most important trial for long-term users
This review examines the link between diabetes and neurodegenerative diseases, explores the effects of antidiabetic agents on neurodegeneration, provides a concise overview of the GLP-1 pathway, and discusses both preclinical and clinical trial outcomes of GLP-1RAs for neurodegenerative diseases, including their effects on cognition in AD and PD
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Most information comes from experts physiological reasoning, indirect evidence (like what happens to patients fitness levels on GLP-1 therapy), and some basic science studies
