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Gallbladder disease , including cholelithiasis and cholecystitis, occurs more frequently with rapid weight loss and has been observed in clinical trials

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what has been observed during a series of studies is its protective antioxidant property: there is a strong positive correlation between oxidative stress and insulin resistance

This discrepancy primarily stems from methodological variations in patient selection, intervention design, and endpoint assessment, rather than contradicting the established biological plausibility of LC's mechanisms