Common side effects shared by both medications: Nausea (most common, usually transient peaks during dose escalation) Vomiting Diarrhea or constipation Decreased appetite and early satiety Bloating or stomach discomfort Injection site reactions Key safety warnings that apply to both drugs: FDA Boxed Warning (both): Possible risk of thyroid C-cell tumors, based on animal studies
It is briefly mentioned in the Drug Interactions section to say the drug delays gastric emptying, and may impact absorption of concomitantly administered oral medications. It is also briefly mentioned in the Pharmacodynamics section, which describes how the drug works
Discussion This study provides new insights into the evolving role of GLP-1 RAs in healthcare, particularly how their use amongst people with overweight or obesity coincides with first-time diagnoses of type 2 diabetes, sleep apnea, and cardiovascular disease
00:02:57 Vickie Danaher Lets start to dig into the specifics with orforglipron and how it compares to oral semaglutide
With over 100 curated dishes and tips on managing side effects, it's a good start to set you up for success