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41,48,49 It has been reported that up to 75% of their metabolism is unproductive due to proton leak (premature leakage of protons through the inner mitochondrial membrane not mediated by ATP synthase) which is staggering, given that insulin secretion occurs in an ATP-dependent manner

Twenty-four-week effects of liraglutide on body composition, adherence to appetite, and lipid profile in overweight and obese patients with type 2 diabetes mellitus

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Abbreviations CAT: Catalase CF: Cisplatin plus 5-fluorouracil DEGs: Differentially expressed genes EC: Esophageal cancer EMT: Epithelialmesenchymal transition ESCC: Esophageal squamous cell carcinoma FC: Fold change FDR: False Discovery Rate FFPE: Formalin-fixed paraffin-embedded GO: Gene Ontology GPx: Glutathione peroxidase GSEA: Gene set enrichment analysis GSH: Glutathione GST: Glutathione S-transferase H&E: Hematoxylin and eosin ICI: Immune checkpoint inhibitors INDELs: Insertions/deletions KEGG: Kyoto Encyclopedia of Genes and Genomes NAC: Neoadjuvant chemotherapy OS: Overall survival PC1: First principal component PCA: Principal Component Analysis PostNAC: After CF-based NAC PPI: Proteinprotein interaction PreNAC: Before CF-based NAC ROS: Reactive oxygen species SNVs: Single-nucleotide variants SOD: Superoxide dismutase TPM: Transcripts per million References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al