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Current Pharmaceutical Design , 16(8), 10441055

Furthermore, animal studies demonstrate that the microbiota in the gut can alter the neurological aspects of depression (103), such as low-grade immune activation (104), the HPA activity (105), altered tryptophan metabolism (106), and neurotrophic factors (107, 108)

It upregulates VEGF, promoting angiogenesis in damaged synovial tissue and cartilage, and stabilizes nitric oxide synthase activity to reduce oxidative stress

In states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide

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