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Lustgarten MS, Bhattacharya A, Muller FL et al (2012) Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications widely used for type 2 diabetes and obesity
The increased fertility from metabolic improvement is a bigger contraceptive concern than drug interaction
NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)
Notably, studies also show that combining these medications with supervised exercise can help maintain weight and fat loss even after stopping the medication
