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Serious side effects are uncommon but can include pancreatitis or dehydration if dosing guidelines aren't followed

It can act on enterocytes and underlying tissue directly from the luminal side

at least 50% of patients receiving 10 or 15 mg of tirzepatide per week achieved a weight loss of 20% and more 6,59,60,61,62 .Tirzepatide was also superior to semaglutide at reducing levels of glycated hemoglobin 63

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By activating the GLP-1 receptor, retatrutide is thought to stimulate insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite effects consistent with the broader GLP-1 receptor agonist class