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We show that senescent cells are primed for ferroptosis, displaying high levels of oxidative stress and intracellular Fe 2+ , but also upregulate GPX4, which prevents the accumulation of oxidized lipids

Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Given the effect of these drugs on eating for pleasure, future studies could explore whether small-molecule GLP-1s can also suppress cravings for other addictive substances