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This anorexic response is largely mediated by neuronal areas within the hypothalamus and brainstem (189193)

The starting dose is usually maintained for several weeks before your healthcare provider recommends increasing to a higher dose

Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone