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Conclusion GLP-1s directly influence bone remodeling through receptor expression on osteocytes and bone mesenchymal stem cells
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The distinction worth understanding is this: prescription GLP-1 medications directly activate GLP-1 receptors and carry FDA approval based on extensive clinical trials
TDO is also activated by IFN- and cortisol [98], as well as glucagon [99]
Before and after data was again not provided so overall % increase/decrease could not be calculated in this subgroup
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