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Synthesis is primarily hindered due to the inhibition of the mTOR signaling pathway (manifested as downregulation of PI3K/Akt/mTORc1 activity), leading to reduced protein synthesis [37]
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Investigations propose that its interaction with pituitary cells might initiate signaling cascades involving phospholipase C, which could influence intracellular calcium release and protein kinase pathways
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Since most of a protein's biological functions depend on its three-dimensional (3D) structure, appropriate folding, stability, and interaction between domains must be considered while creating multi-domain recombinant proteins
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