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Start your intake How Semaglutide May Trigger Muscle Cramping in the Legs Semaglutide influences multiple body systems, and leg cramps can emerge from several interconnected mechanisms

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J Orthop Surg Res 18 , 386 (2023)

Several mechanisms have been suggested [5,17,33,34]: (1) reduced intrinsic factor secretion, (2) decreased vitamin B12 release from protein complexes, (3) microbial overgrowth due to slowed intestinal transit, and (4) decreased vitamin B12-intrinsic factor complex receptors

Many patients report reduced cravings and improved appetite control during treatment