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Taken together, activating GLP-1R not only protected fibroblasts against lactate-induced NLRP3 inflammasome activation, but also inhibited histone lactylation by reducing the expression of p300 thereafter suppressing the transcription of profibrotic genes

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Potential side effects of GLP-1 medications include nausea, vomiting, diarrhea and constipation, which may improve over time