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In a meta-analysis of 16 RCTs of adults with diabetes and CKD (four of which included people with type 1 diabetes), spironolactone added to standard therapy was associated with a reduction in 24 h urinary albumin/protein excretion [66]
But the gap between the two compounds may narrow in real-world settings where adherence and dose optimization are less consistent
SLC7A8 can activate the mTORC1 signaling pathway, increase glutamine uptake and glutathione synthesis, and further aggravate the drug resistance of tumor cells [77]
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Heppner et al., 2015b)
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