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Paul, S
Even specific DPP4 inhibitors have potential side effects (gastro-intestinal, cardiovascular, infective, inflammatory, and allergic events) due to their prolonging the action of a number of neuropeptides and chemokines as well as to their non-enzymatic functions.
The efficacy of these products has not been confirmed by FDA-approved research
Vagal efferents, in turn, modulate gastrointestinal secretion, motility, and even local immune responses [28]
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