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with a mean increase of 8 points) and tirzepatide (SUMMIT), appears to be greater than what has been reported for other HFpEF trials investigating the benefits of angiotensin receptorneprilysin inhibitor (Paragon-HF), sodiumglucose cotransporter 2 inhibitors (EMPEROR-Preserved, DELIVER) and spironolactone (TOPCAT)
Patients sometimes ask me if one of the two has fewer side effects, and I can now confidently say they are similar in that regard
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For example, UK SmPCs for GLP-1 receptor agonists advise caution in patients with a history of pancreatitis or gallbladder disease, and include precautionary guidance regarding thyroid symptoms (such as a neck mass, difficulty swallowing, or hoarseness) that should be reported promptly
& Keller, U
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