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(Sun et al., 2022), discovered that propofol, propofol injection emulsion, and phosphopropofol disodium significantly enhanced the antitumor effects of doxorubicin and paclitaxel while inducing changes associated with ferroptosis

Some studies report that L-carnitine can also activate the activity of pyruvate dehydrogenase by lowering the acetyl-CoA/CoA ratio, promoting pyruvate oxidation and reducing lactate accumulation, thus improving the sustained capacity for anaerobic exercise

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Rothan et al

This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism