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Key Characteristics & Symptoms Individuals with PWS may experience a combination of physical, behavioral, and metabolic symptoms: Physical Features Almond-shaped eyes Narrow bridge of the nose Short stature Small hands and feet Thin upper lip & downturned mouth corners Scoliosis Obesity (due to relentless appetite) Behavioral & Cognitive Features Hyperphagia (uncontrolled hunger) Learning difficulties Low muscle tone in infancy Temper outbursts Obsessive-compulsive behaviors Low impulse control Risk of psychosis in adolescence/adulthood Hormonal Abnormalities Hypogonadism Delayed or incomplete puberty Low growth hormone Reduced metabolic rate Diagnosis Diagnosis is typically confirmed through genetic testing , including: Methylation analysis FISH (fluorescent in situ hybridization) Microarray Early testing is essential for prompt intervention

1,7-9 There is general agreement, however, that abnormal processing of pain signals in the brain (central sensitization) and heightened sensitivity along peripheral pain pathways are key mechanisms underlying fibromyalgia

It has also shown an ability to course-correct (e.g., undertaking huge cost cuts now to preserve earnings)

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