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NIH, National Library of Medicine, Office of Dietary Supplements - Vitamin C Fact Sheet for Health Professionals 2
In biological systems, over 95% of circulating native IGF-1 is sequestered in ternary complexes with IGF binding proteins (primarily IGFBP-3) and the acid-labile subunit (ALS), meaning only a small free fraction is available to activate IGF-1R at any given time
However, these modifications must be balanced against potential effects on biological activity and safety
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