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doi: 10.1016/j.biopha.2021.111315 70 HotamisligilGS
Most carnitine is stored in muscle
(Manny) Simons, PhD MBA, CEO and Co-Founder Number of Employees: 100+ Stage: Acquired (by Eli Lilly) Financial Snapshot: Acquisition valued at $610 million ($487 million in cash, plus CVR) Notable Investors: 5AM Ventures, New Enterprise Associates (NEA) Key Products: Akouos does not yet market any products
To enhance the pharmacological properties of the ruthenium catalyst, provide cancer selectivity for the treatment, and enable the treatment of challenging hypoxic tumors, the metal complexes were covalently conjugated to the side chains of polymers with a carbon fluorinated moiety that could co-deliver oxygen to the tumor
Having more control over the pace and dose could help mitigate potential side effects associated with the medication at therapeutic doses, such as nausea, diarrhea and constipation
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