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As with other complex diseases, the next era likely involves precision, combination therapypairing antiamyloid agents with treatments aimed at metabolic, inflammatory, vascular, and synaptic pathways

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Discussion Present dose-response meta-analysis revealed that L-carnitine intake has beneficial effects on glycemic indices by reducing FBG, HbA1c, and HOMA-IR, whereas insulin levels were not changed in the overall analysis

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The metabolite GLP-1 (9-36) is neuroprotective and anti-inflammatory in cellular models of neurodegeneration