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The medication enters your bloodstream through these membranes directly, bypassing the digestive system entirely

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However, injection site reactions occur in 2-10% of patients, and rare allergic skin reactions including rash, hives, and itching have been documented

Notably, these effects were not mimicked by E alone, which failed to rescue cycle perturbations and had a discernible uterotrophic action, but were replicated, in terms of reversal of irregularities of the ovarian cycle, by GLP1 alone, which nonetheless did not elevate LH levels