In simpler terms, Tirzepatide works by mimicking the action of the naturally occurring hormones GIP and GLP-1, which play crucial roles in regulating blood sugar levels and promoting satiety
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1 Cardiovascular and metabolic diseases, including obesity, remain important areas of unmet medical need, and we plan to continue applying our global capabilities to advance a pipeline of investigational treatments that have the potential to fill critical gaps in patient care, including continued development of our oral GIPR antagonist candidate and other earlier obesity programs, Chris Boshoff, MD, PhD, chief scientific officer and president of Research and Development at Pfizer, said in a news release
5 WARNINGS AND PRECAUTIONS WARNINGS AND PRECAUTIONS SECTION 5.1 Risk of Thyroid C-Cell Tumors SPL UNCLASSIFIED SECTION In both sexes of rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]
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