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Analyses were performed using SPSS 23.0 (IBM, Armonk, NY, United States) statistical software

47,48 These synthetic protein preparations exhibit partial or complete amino acid sequence homology with endogenous GLP-1, rendering them resistant to degradation which resulting in a prolonged half-life and heightened biological activity

Diabetes-related atherosclerosis affects the large blood vessels in the lower extremities, leading to occlusive peripheral arterial disease and an increased risk of gangrene and amputation

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