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The conformational changes in IGF-IR create docking sites for its substrates, such as Shc and InsR substrates (IRS), which relay the signaling to downstream effectors including PI3K, MAPK, and STAT3
By acting as a potent antioxidant, glutathione helps protect liver cells from damage caused by free radicals
Some patients have reported an upset stomach, vomiting, nausea, diarrhea, headaches and some dizziness
Glutathione is generally very well tolerated at therapeutic doses
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