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Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)

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The acceleration of cell turnover caused by tretinoin pushes impurities to the surface more rapidly, resulting in a temporary increase in acne, whiteheads, and blackheads lasting anywhere from 4-6 weeks

2.4.5.2 Liquid chromatography-mass spectrometry analysis conditions The analyzing instrument was a liquid-mass spectrometer system consisting of ACQUITY UPLC I-Class plus ultra-high performance liquid tandem high-resolution mass spectrometer