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Inflammation phase: cytokine modulation, reduced excessive inflammation

Constipation or diarrhea may also appear

Cagrilintide's amylin mechanism (different pathway) How cagrilintide works: Amylin receptor agonist Long-acting weekly injection Investigational (not FDA approved) Different receptors than GIP/GLP-1 Amylin pathway effects: Very strong gastric emptying delay (stronger than GLP-1) Central appetite suppression (area postrema) Reduces meal frequency Suppresses glucagon Enhances satiety Cagrilintide monotherapy results: 10-12% average body weight loss Significant GI side effects (stronger gastric slowing) Currently in Phase 3 trials Not yet available pharmaceutically See our cagrilintide weight loss , cagrilintide dosing , and cagrilintide and semaglutide guides

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doi: 10.1016/0020-7489(94)90079-5 40 PiersLSDiggaviSNRijskampJVan RaaijJMAShettyPSHautvastJGAJ