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Diabetes Spectrum 2006
IGF-DES Receptor Binding Specificity Competitive binding and receptor cross-linking experiments confirmed that both IGF-1 and des-(1-3)IGF-1 bind exclusively to the type 1 IGF receptor in L6 myoblasts, rat vascular smooth-muscle cells, and human lung fibroblasts with des-(1-3)IGF-1 demonstrating greater apparent potency in these assays, attributable to its low affinity for the competing 38 kDa IGFBP rather than differences in intrinsic receptor affinity
Promotes weight loss, which is why its also used for obesity management
It is cold (great for nausea weeks)
In an email to CBC News, Health Canada said it "authorized the drug after a thorough review of evidence provided by the company demonstrating that the drug meets Health Canada's criteria for safety, effectiveness and quality for generic drugs." It continued to say that generic semaglutide drug submissions are complicated, and the manufacturer must show that any differences do not affect the drug
