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In rats treated with methylprednisolone, simultaneous administration of ipamorelin increased periosteal bone formation rate four-fold compared to the glucocorticoid-only group, effectively reversing the catabolic bone effects
Immediate oral semaglutide use was therefore associated with an incremental cost-effectiveness ratio (ICER) of GBP 9404 per QALY gained versus continuing metformin plus an SGLT-2 inhibitor for a further 2 years for the treatment of type 2 diabetes in the UK
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