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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

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however, clinically viable GLP-1 receptor agonists did not emerge until advances in peptide stabilization, delivery, and dosing strategies were achieved (Campbell and Drucker, 2013