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This process known as first-pass metabolism or gastric first-pass metabolism acts as a partial filter, breaking down some alcohol before it enters systemic circulation

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Treatment of pernicious anaemia or vitamin B12 deficiency typically involves 1mg injections daily or alternate daily for 1 to 2 weeks meaning the dose is five thousand times smaller than the single dose used in cyanide poisoning, and therefore urinary discolouration is not expected to be observed