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While this review infers that semaglutides DR risk may stem from insulins pro-angiogenic actions, direct evidence is currently limited
For inducing remission in mild-to-moderate disease , topical (rectal) aminosalicylates are first-line for proctitis and left-sided colitis
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In the gastrointestinal tract, GLP-1 delays gastric emptying through vagal activation and effects on smooth muscle, increases beta cell proliferation and survival as well as glucose-dependent insulin secretion, suppresses glucagon secretion, and reduces hepatic fat accumulation through fatty acid oxidation as well as hepatic gluconeogenesis [43]
