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These cellular stressors activate inflammatory cascades involving Kupffer cells, recruited macrophages, and other immune cells, perpetuating hepatic inflammation through secretion of inflammatory mediators and cellular damage signals [7]

Its important for these individuals to have realistic expectations and to use these medications as part of a broader lifestyle change, including ongoing diet and exercise, under the guidance of a healthcare provider to ensure safety and effectiveness

So far, early clinical data suggest amylin agonists offer milder side effects, and preclinical data support the hypothesis that their mechanism of action favors fat loss over lean mass loss

Many GLP-1 agonists are given by injection