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Patients with certain medical conditions should exercise caution: those with Leber's hereditary optic neuropathy (a rare genetic condition) may experience optic nerve damage with high-dose cyanocobalamin

The findings provide a powerful counterpoint to the challenge of low medication adherence in real-world settings, where many patients stop taking GLP-1s before they can see the full clinical benefit

Net gains in sperm health or egg quality are observed in men and women, respectively, in trials