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When a B12 deficiency occurs, its usually because you dont consume enough of it or your body doesnt absorb enough of it when you do consume it

Indeed, metformin attenuated palmitate-induced UPR events in RINm5F rat insulinoma cells (30) and HepG2 cells (31), and alleviated hepatic ER stress of Male albino Wistar rats induced by a high-calorie diet (29)

And he's now gone on to start his own lab at the University of Oregon Health Science Center

Thermodynamically stable ionic-liquid micro-emulsions pioneer pathways for topical delivery and peptide application

doi: 10.1016/j.compbiomed.2023.107780 136 MaTLiXZhuYYuSLiuTZhangXet al