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They should be considered superior in most patients, including those with HF and CKD.3 However, ischaemia prevention is superior for GLP-1 RAs, thus making them preferable in patients with predominant ASCVD risk.3 Differences in routes of administration and adverse effect profiles may also play a role in prescription decisions

Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell

However, the authors of this study noted that there were no clinically significant differences, and both drugs were effective for their intended uses

The Proceedings of the Nutrition Society, 59(4), 595600