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The serum-induced increase in p53 ubiquitination was blocked by a PI3K inhibitor, suggesting that phosphorylated Akt enhances the ubiquitination-promoting function of MDM2, determining reduction of the p53 protein

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Practice Guide for DPP4 Inhibitors Dipeptidyl peptidase-4 (DPP-4) inhibitors display structural heterogeneity, leading to differences in pharmacokinetic (PK) and pharmacodynamic (PD) properties between this class of drugs