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In a study on 1000 community elderly, it was found that raised tHcy or MMA levels, as well as low holoTC (holotranscobalamin is the circulating form of B12 that is bound to transcobalamin) levels were related to cognitive deficit and reflexes impaired when B12 were within normal range

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During calorie restrictionespecially rapid weight lossthe body may break down muscle tissue for energy, which can slow metabolism and make long-term weight maintenance more difficult

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