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VK2 (MK4 or MK7) causes osteocalcin to undergo -carboxylation, resulting in carboxylated osteocalcin (cOC), which may strengthen bones by encouraging mineralization (150)
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Despite its favorable profile, caution should be exercised when administering it to patients as careful monitoring of individual factors remains vital in ensuring optimal safety and efficacy when using this therapy for musculoskeletal conditions like tendonitis
Additionally, in the SELECT trial, adults with obesity and without diabetes receiving semaglutide had a 20% lower risk for major adverse CV events compared with placebo (HR = 0.8
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