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The primary challenge lies in their inherent pharmacokinetic properties, in particular their low oral bioavailability
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Cardiovascular outcome studies have shown cardiovascular advantages associated with certain GLP-1 receptor agonists, especially in those with pre-existing cardiovascular illness
Such interaction between the ECM and the actin cytoskeleton through integrins allows integrins to maintain cytoskeletal organization, cell motility and intracellular-signaling pathways such as cell survival, cell shape, cell proliferation, and angiogenesis (Luo et al., 2007)
Most critically, patients with active malignancies or significant cancer risk factors may not be appropriate candidates due to the potential for promoting tumor growth and metastasis through angiogenesis stimulation
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